Past Events

Dr. Dorothy Schafer

Microglial Phagocytic Mechanisms Governing Brain Plasticity

April 19, 2018 12:00 pm - 1:00 pm

Neurological Institute Alumni Auditorium

Microglia are dynamic sensors of their extracellular environment and are intimately associated with synapses within neural circuits. Our previous work has demonstrated that microglia sculpt synaptic connectivity in the developing rodent visual system by phagocytosing a subset of less active synapses. Going forward, we are now using another sensory system, the mouse barrel cortex, to dissect how neural activity and sensory experience modulate microglial phagocytic function and plasticity of neural circuits. Ultimately, we are applying these mechanisms to elucidate how dysregulation of synaptic phagocytosis by microglia can play a pivotal role in synapse pathology in neurological disease.

Graduate Student Research in Progress Talks

Presenters: Rick Warren and Joshua Chalif

April 16, 2018 5:00 pm - 6:00 pm

Jerome L Greene Science Ceneter, L7-119, 3227 Broadway, New York NY

Dr. Michael Sofroniew

Astrocyte roles in CNS repair and regeneration

April 12, 2018 12:00 pm - 1:00 pm

Neurological Institute Alumni Auditorium

Dr. Lisa Goodrich

Wired up for hearing: the nature and origin of spiral ganglion neuron heterogeneity

April 5, 2018 12:00 pm - 1:00 pm

Neurological Institute Alumni Auditorium

Dr. John Krakauer

Motor planning and motor skill in health and disease

March 29, 2018 12:00 pm - 1:00 pm

Neurological Institute Alumni Auditorium

First, the ideas of motor planning and imitation will be linked through the example of apraxia. Second, the vexed issue of motor skill and how it relates to cognition and memory will be discussed. Finally, the notion of recovery from brain injury as a form of skill learning will be examined.

CANCELLED - Dr. Kevin Franks

Neural Circuits for Odor Coding in Piriform Cortex

March 22, 2018 12:00 pm - 1:00 pm

Neurological Institute Alumni Auditorium

Animals rely on olfaction to find food, attract mates and avoid predators. To support these behaviors, they must be able to reliably identify a given odor over a large range of odorant concentrations, while nevertheless retaining the ability to discriminate small differences in concentration. Through a combination of theoretical and experimental investigations, we identified complementary coding strategies for generating non-interfering representations of odor identity and odor intensity in mouse piriform cortex. We next examined the neural circuit operations that underlie these representations. We find that intrinsic recurrent circuitry is required for concentration-invariant odor recognition and for stabilizing odor representations over time and across variable stimulus conditions. Our results therefore highlight the specific and crucial roles that intrinsic cortical circuitry play in shaping sensory representations.

Graduate Student Research in Progress Talks

Presenters: Catherine Braine

March 19, 2018 5:00 pm - 6:00 pm

HHSC 5th Floor Conference Room

Dr. Li-Huei Tsai

Gamma frequency entrainment using sensory stimuli confers neuroprotection across multiple brain regions

March 15, 2018 12:00 pm - 1:00 pm

Neurological Institute Alumni Auditorium

Dr. Scott Waddell

Re-evaluation of Learned Information in Drosophila

March 8, 2018 12:00 pm - 1:00 pm

Neurological Institute Alumni Auditorium

Dr. Brenda Bloodgood

Decoding Circuit Activity with an Immediate Early Gene

March 1, 2018 12:00 pm - 1:00 pm

Neurological Institute Alumni Auditorium

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