Tuesday, September 25, 2018 - 4:00pm to 5:00pm
Neurological Institute Auditorium, 1st floor, 710 West 168th Street, New York
Sleep deprivation is harmful and can even cause death through unknown means. Many things go wrong in sleep deprived animals so it appears difficult to pinpoint a specific detrimental event. We show that sleep deprived flies, and mice, accumulate reactive oxygen species (ROS) and experience oxidative stress - in their intestines. Clearing ROS allows normal survival in the complete absence of sleep. Our data provide the first direct link between sleep deprivation-induced death and a specific physiological change, and offer an explanation for why this state is essential for survival. In the second part of my talk, I will describe how the brain decides (on a molecular and circuit level) if mating is appropriate in a given situation, and how it motivates the animals to engage in a courtship ritual.
Dragana Rogulja, Ph.D.
Harvard Medical School