Cell Type-Specific Profiling and Genetic Screening in Mouse Models of Huntington's Disease

Thursday, June 14, 2018 - 12:00pm to 1:00pm
Neurological Institute Alumni Auditorium
Huntington’s disease (HD) is the most common inherited neurodegenerative disorder, and is characterized by early and most dramatic loss of neurons in the caudate and putamen as well as a debilitating triad of cognitive, motor, and psychiatric symptoms. The huntingtin gene was first linked to HD over twenty years ago, yet to date there is neither a precise molecular explanation for the cell loss that is seen in human patients, nor a curative therapeutic. In my talk, I will describe our efforts over the last few years to advance our understanding of the mechanistic basis of HD. We have combined the use of cell type-specific gene expression profiling with in vivo genetic screening to reveal transcriptional pathways perturbed by mutant Huntingtin protein, as well as the genes that help neurons survive in HD.
Dr. Myriam Heiman
Home Institution: 
Massachusetts Institute of Technology
Event Types: 
Neurobiology Seminars