Joshua A. Gordon, MD, PhD

Departments And Divisions

  • Department of Psychiatry
  • Associate Professor of Psychiatry
  • Associate Director, Adult Psychiatry Residency Program
Joshua A. Gordon, <span>MD, PhD</span>
Cloning of genes which predispose to neuropsychiatric illness is proceeding rapidly of late. Yet identifying such predisposition genes is but a first step in understanding the pathophysiology of mental illnesses. We study genetic models of these diseases from an integrative neuroscience perspective, focused on understanding how a given disease mutation leads to a behavioral phenotype in disease-related mouse models. To this end, we employ a range of systems neuroscience techniques, including in vivo anesthetized and awake behaving recordings.

Board Certifications

  • Psychiatry

    Education & Training

  • University of California San Francisco School of Medicine
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Residency: New York State Psychiatric Institute

Locations

  • Herbert Pardes Building of the New York State Psychiatric Institute

    1051 Riverside Drive
    Unit: 87
    New York, NY 10032

Provider Affiliations

  • NewYork-Presbyterian/Columbia

Lab Locations

  • NYSPI-Kolb Research Building

    622 West 168th Street
    Room 140
    New York, NY 10032
    Phone:
    646-774-7116
    Fax:
    646-774-7101
    Lab Phone:
    646-774-7111
    Email:
    jg343@columbia.edu

Research Interests

  • Cognitive/Systems Neuroscience
  • Neurogenetics
  • Models of Psychiatric Disorders
  • Synapses and Circuits
  • Neurobiology of Disease

Publications


Stujenske, J.M., E. Likhtik, M.A. Topiwala, and J.A. Gordon (2014). Fear and safety engage competing patterns of theta-gamma coupling in the basolateral amygdala. Neuron, 83:919-933.

Likhtik, E., J.M. Stujenske, M. Topiwala, A.Z. Harris, and J.A. Gordon (2014). Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety. Nat. Neurosci. 17:106-113

O’Neill, P.-K., J.A. Gordon, and T. Sigurdssson (2013). Theta oscillations in the medial prefrontal cortex are modulated by spatial working memory and synchronize with the hippocampus through its ventral subregion. J. Neurosci. 33:14211-14224.

Ahmari, S.E., T. Spellman, N.L. Douglass, M.A. Kheirbeck, K. Deisseroth, J.A. Gordon, R. Hen (2013). Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science 340:1234-1239. 

Parnaudeau, S., P.K. O’Neill, S. Bolkan, R.D. Ward, A.I. Abbas, B.L. Roth, P. Balsam, J.A. Gordon, and C. Kellendonk (2013). Inhibition of medio-dorsal thalamus disrupts thalamo-frontal connectivity and cognition. Neuron 77:1151-1162. 

Adhikari, A., M.A. Topiwala, and J.A. Gordon (2011). Single units in the medial prefrontal cortex with anxiety-related firing patterns are preferentially influenced by ventral hippocampal activity. Neuron 71:898-910.

Sigurdsson, T., K.L. Stark, M. Karayiorgou, J.A. Gogos, and J.A. Gordon (2010). Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia. Nature 464:763-767.

For a complete list of publications, please visit PubMed.gov