For over forty years, my research has focused on the molecular biology of learning and memory. The work in my laboratory spans many levels of analysis and disciplines. We combine behavioral, electrophysiological, cellular, and molecular biological approaches to delineate the changes that underlie simple forms of learning and memory in invertebrates and vertebrates. My lab helped pioneer the generation and use of genetically modified mice to examine the mechanisms of long-term potentiation in the mammalian hippocampus and its relation to spatial memory and maintenance. In the course of this work, we identified the existence of functional prions in the brains of Aplysia and mice that are critical for the maintenance of long-term memory. In recent years we have increasingly focused our efforts on deciphering the molecular mechanisms and behavioral deficits underlying psychiatric disorders including post-traumatic stress disorder (PTSD), schizophrenia, and age-related memory loss.
2000, Nobel Prize in Physiology or Medicine
Senior Investigator, Howard Hughes Medical Institute
Scherma M, Qvist JS, Asok A, Huang SC, Masia P, Deidda M, Wei YB, Soni RK, Fratta W, Fadda P, Kandel ER, Kandel DB, Melas PA. (2020) Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine. Proc Natl Acad Sci USA 117: 9991-10002.
Rayman JR, Hijazi J, Li X, Kedersha N, Anderson PJ, Kandel ER. (2019) Genetic Perturbation of TIA1 reveals a Physiological Role in Fear Memory. Cell Rep 26: 2970–83.
Kosmidis S, Polyzos A, Harvey L, Youssef M, Denny CA, Dranovsky A, Kandel ER. (2018) RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss. Cell Rep 25:959–973.
Fioriti L, Myers C, Huang Y-Y, Li X, Stephan J, Trifilieff P, Kosmidis S, Drisaldi B, Pavlopoulos E, Kandel ER. (2015) The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3. Neuron 86: 1433-48.
Pavlopoulos E, Jones S, Kosmidis S, Close M, Kim C, Kovalerchik O, Small SA, Kandel ER. Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48. (2013) Sci Transl Med 5:200ra115.
Rajasethupathy P, Antonov I, Sheridan R, Frey S, Sander C, Tuschl T, Kandel ER. (2012). A Role for Neuronal piRNAs in the Epigenetic Control of Memory-Related Synaptic Plasticity. Cell 149: 693-707.
Levine A, Huang Y, Drisaldi B, Griffin EA Jr, Pollak DD, Xu S, Yin D, Schaffran C, Kandel DB, Kandel ER. (2011) Molecular mechanism for a gateway drug: epigenetic changes initiated by nicotine prime gene expression by cocaine. Sci Transl Med 3: 107ra109.
Simpson, E.H., Kellendonk, C., and Kandel, E.R. (2010) A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia. Neuron 65:585-596.
Si, K., Choi, Y., White-Grindley, E., Majumbar, A., and Kandel, E.R. (2010) Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation. Cell 140:421-435.
For a complete list of publications, please visit PubMed.gov