Artificially modulating positive and negative memories in healthy and maladaptive states

Thursday, January 11, 2018 - 12:00pm to 1:00pm
Hellman Auditorium, NY State Psychiatric Institute, Pardes Building, 1051 Riverside Drive, New York NY
With the accumulation of our knowledge about how memories are formed, retrieved, and updated, neuroscience is now reaching a point where discrete memories can be identified and manipulated at rapid timescales. Here, I will review recent advances in memory research that combine transgenic, optogenetic, in vivo imaging, and viral-tracing strategies to visualize and manipulate discrete sets of cells sufficient to modulate mnemonic processes. I will focus on three lines of research: acutely activating and visualizing hippocampus cells to drive the behavioral expression of positive and negative memories; acutely activating cells processing positive memories to suppress the return of fear; and, chronically activating cells processing positive and negative memories to enduringly modulate social and hedonic-like states. Together, I propose that defined sets of hippocampus cells provide a neuronal node sufficient to permanently alter healthy and maladaptive states
Dr. Steve Ramirez
Home Institution: 
Boston University
Event Types: 
Neurobiology Seminars