Thursday, April 19, 2018 - 12:00pm to 1:00pm
Neurological Institute Alumni Auditorium
Microglia are dynamic sensors of their extracellular environment and are intimately associated with synapses within neural circuits. Our previous work has demonstrated that microglia sculpt synaptic connectivity in the developing rodent visual system by phagocytosing a subset of less active synapses. Going forward, we are now using another sensory system, the mouse barrel cortex, to dissect how neural activity and sensory experience modulate microglial phagocytic function and plasticity of neural circuits. Ultimately, we are applying these mechanisms to elucidate how dysregulation of synaptic phagocytosis by microglia can play a pivotal role in synapse pathology in neurological disease.
Dr. Dorothy Schafer
Univeristy of Massachusetts Medical School