Franck Polleux, PhD

Departments and Divisions

  • Department of Neuroscience

Academic Appointments

  • Professor of Neuroscience
Franck Polleux, PhD

Lab Locations

  • Jerome L. Greene Science Center

    3227 Broadway
    Quad 5C
    New York, NY 10027
    (212) 853-0407

Past Positions

  • July 2010 to October 2013: Professor, The Scripps Research Institute- La Jolla, CA.  Dorris Neuroscience Center
  • July 2008 to June 2010: Associate Professor,  University of North Carolina at Chapel Hill, Neuroscience Center, Department of Pharmacology
  • October 2002 to July 2008: Assistant Professor,  University of North Carolina at Chapel Hill, Neuroscience Center, Department of Pharmacology
  • April 2000 to Sept. 2002: Research Investigator,  INSERM (French National Institute of Health) U371 - France
  • June 1997 to April 2000: Post-doctoral scholar,  Laboratory of Anirvan Ghosh, Ph.D., Johns Hopkins University, School of Medicine Baltimore, MD (USA)

Honors and Awards

  • 1993-1997 Graduate Training Award from the French Ministry of Research and Technology
  • 1999 Albert L. Lehninger Research Prize for Post-doctoral Research - Johns Hopkins University
  • 2000-2001 INSERM-CFB award for a European collaborative project with the group of Dr Vanderhaeghen, University of Brussels –Belgium.
  • 2004-2007 March of Dimes Birth Defect Foundation Award
  • 2005-2009 Pew Scholar Award in Biomedical Sciences
  • 2005-2007 NARSAD Young Investigator Award
  • 2007-2009 NARSAD Young Investigator Award
  • 2008-2012 Permanent member on NIH Study Section Neuronal Differentiation, Plasticity and Regeneration (NDPR)
  • 2010-2012 Co-Chair (2010) and Chair (2012) Gordon Conference, Neural Development - Salve Regina, RI
  • 2012 Member of the Editorial Board of PLoS Biology
  • 2015 Recipient of the 2015 Prize from the Fondation Roger de Spoelberch in Neuroscience (Scientific award for mid-career neuroscientists)

Research Interests

  • Axon Pathfinding and Synaptogenesis
  • Cell Specification and Differentiation
  • Synapses and Circuits

Lab Members

  • Andres Villegas, Graduate Student
  • Daniel Virga, Graduate Student
  • Victoria Hewitt, Postdoc
  • Heike Blockus, Postdoc
  • Ewoud Schmidt, Postdoc
  • Daniel Iascone, Graduate Student
  • Melba Colon, Administrative Assistant
  • Justin O'Hare, Postdoc


Attila Losonczy, Associtate Professor, Dept Neuroscience - Zuckerman Mind Brain Behavior Institute. Columbia University


Lewis, T.L.*, Kwon SK.*, Lee A., Shaw and Polleux F. (2018) MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size Nature Communications 9:5008.* Co-first authors.

Courchet V., Roberts, A.J., Del Carmine, P. Lewis TL. Polleux F. * Courchet J. * (2018) Happloinsufficiency of autism candidate gene NUAK1 impairs cortical development and behavior. Nature Communications9:4289. * co-corresponding authors

Hirabayashi Y., Tapia JC., Polleux F. (2018) Correlated Light-Serial Scanning Electron Microscopy (CoLSSEM) for ultrastructural visualization of single neurons in vivo. Scientific Reports 8:14491.

Hirabayashi Y.*, Kwon S-K.*, Paek H., Pernice W.M., Paul M.A., Lee J., Erfani P., Raczkowski A., Petrey D.S., Pon L. A. and Polleux F. (2017) ER-mitochondria tethering by PDZD8 regulates Ca2+dynamics in mammalian neurons. Science 358(6363):623-630. * Co-first authors.
Lewis, T. L., Jr., Turi, G. F., Kwon, S. K., Losonczy, A. and Polleux, F. (2016) Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo. Curr Biol. 26:2602-2608.
Fossati M, Pizzarelli R, Schmidt ER, Kupferman JV, Stroebel D, Polleux F*,Charrier C*. (2016) SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.Neuron. 91(2):356-69. *Co-senior corresponding authors.
Kwon S.K., Sando R. 3rd, Lewis T.L, Hirabayashi Y, Maximov A, and Polleux F.(2016) LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons.PLoS Biol.14(7):e1002516
Courchet J.*, Lewis T. Jr*, Aizawa S. and Polleux F. (2013) Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture. Cell 153:1510-1525.
Mairet-Coello G, Courchet J, Pieraut S, Courchet V, Maximov A and Polleux F. (2013) The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Abeta Oligomers through Tau Phosphorylation. Neuron 78:94-108.
Charrier C*, Joshi K*, Coutinho-Budd J, Kim JE, Lambert N, de Marchena J, Jin WL, Vanderhaeghen P, Ghosh A, Sassa T, Polleux F. (2012) Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. Cell 149:923-35.
Yi J.J., Barnes A.P., Hand R., Polleux F. and Ehlers M.D. (2010) TGFβ signaling specifies axons during brain development. Cell 142:144-57.
Guerrier S., Coutinho-Budd J., Sassa T., Vincent-Jordan N., Frost A., and Polleux F. (2009) The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell 138:990-1004.
Bortone D. and Polleux F. (2009) KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner. Neuron 62:53-71. (Featured Article)

For a complete list of publications, please visit