Joriene C. De Nooij, PhD

Departments And Divisions

  • Department of Neurology
  • Assistant Professor of Neurological Sciences (in Neurology)
  • CTNI Scholar
Joriene C. De Nooij, <span>PhD</span>

    Education & Training

  • PhD, 1998 Utrecht University (Netherlands)

Lab Locations

  • College of Physicians and Surgeons (P&S)

    630 West 168th Street
    Room 4-447 (office), Room 4-401 (lab)
    New York, NY 10032
    (212) 305-3624
    Lab Phone:
    (212) 305-1633

Contact Info

  • (212) 305-3624

Past Positions

July 2006 - February 2017   Associate Research Scientist, Department of Biochemistry and Molecular Biophysics, Columbia University.

May 1999 - June 2006    Postdoctoral Scholar, Department of Biochemistry and Molecular Biophysics, Columbia University.


Society for Neuroscience

Honors & Awards

2015-2017       TFFI Innovation award (together with Hynek Wicherle, Joachim Scholz, Ellen Lumpkin)               

2000-2003       Fellow of the Helen Hay Whitney Foundation.

Research Interests

  • Sensory neuron specification and differentiation
  • Cellular/Molecular/Developmental Neuroscience
  • Proprioception
  • Stem cell biology
  • Peripheral neuropathy/Disease modeling


Woo, S.-H., Lukacs, V., de Nooij, J.C., Zaytseva, D., Criddle, C.R., Francisco, A., Jessell, T.M., Wilkinson, K.A., and Patapoutian, A. Piezo2 is the principal mechanotransduction channel for proprioception. Nat Neurosci. 18:1756-1762, 2015.

De Nooij, J.C., Simon, C.M., Simon, A., Doobar, S., Steel, K.P., Banks, R.W., Mentis, G.Z., Bewick, G.S., and Jessell, T.M. The PDZ-domain protein Whirlin facilitates mechanosensory signaling in mammalian proprioceptors. J. Neurosc., 35: 3073-3084, 2015.

De Nooij, J.C., Doobar, S., and Jessell, T.M. Etv1 inactivation reveals proprioceptor subclasses that reflect the level of NT3 expression in muscle targets. Neuron 77:1055-1068, 2013.

Chen, A.I., de Nooij, J.C., and Jessell, T.M. Graded activity of transcription factor Runx3 specifies the laminar termination pattern of sensory axons in the developing spinal cord. Neuron 49: 395-408, 2006.

Kramer, I., Sigrist, M., de Nooij, J.C., Taniuchi, I., Jessell, T.M., and Arber, S. A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. Neuron 49: 379-393, 2006.

Chen, C.L., Broom, D.C., Liu, Y., de Nooij, J.C., Li, Z., Cen , C., Samad, O.A., Jessell, T.M., Woolf, C.J., and Ma, Q. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron 49: 365-377, 2006.

For a complete list of publications, please visit