James E. Goldman, MD, PhD

James E. Goldman, MD, PhD

Research Interest

  • MD, PhD, 1976 Neurobiology (PhD), New York University School of Medicine
  • Residency: Albert Einstein Medical Center
  • Fellowship: 1980 Albert Einstein Medical Center

Association for the Advancement of Science

Society for Neuroscience

American Assocation of Neuropathologists

American Association for Neurochemistry

Sosunov AA, McGovern RA, Mikell CB, Wu X, Coughlin DG, Crino PB, Weiner HL, Ghatan S, Goldman JE, McKhann GM. Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities. Acta Neuropathol Commun. 2015 Apr 2;3(1):17. doi: 10.1186/s40478-015-0191-5. PMID: 25853525.


Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A, Sonders MS, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne F, Dwork AJ, Goldman J, Sulzer D. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.  Neuron. 2014 Sep 3;83(5):1131-43. doi: 10.1016/j.neuron.2014.07.040. Epub 2014 Aug 21. Erratum in: Neuron. 2014 Sep 17;83(6):1482. PMID: 25155956

Mayer JA, Griffiths IR, Goldman JE, Smith CM, Cooksey E, Radcliff AB, Duncan ID. Modeling the natural history of Pelizaeus-Merzbacher disease. Neurobiol Dis. 2015 Mar;75:115-30. doi: 10.1016/j.nbd.2014.12.023. Epub 2015 Jan 3. PMID: 25562656.

Collins-Praino LE, Francis YI, Griffith EY, Wiegman AF, Urbach J, Lawton A, Honig LS, Cortes E, Vonsattel JP, Canoll PD, Goldman JE, Brickman AM. Soluble amyloid beta levels are elevated in the white matter of Alzheimer's patients, independent of cortical plaque severity. Acta Neuropathol Commun. 2014 Aug 17;2:83. doi: 10.1186/PREACCEPT-3091772881321882. PMID: 25129614.

Walker AK, Daniels CM, Goldman JE, Trojanowski JQ, Lee VM, Messing A. Astrocytic TDP-43 pathology in Alexander disease. J Neurosci. 2014 May 7;34(19):6448-58. doi: 10.1523/JNEUROSCI.0248-14.2014. PMID: 24806671.

Sosunov AA, Wu X, Tsankova NM, Guilfoyle E, McKhann GM 2nd, Goldman JE. Phenotypic heterogeneity and plasticity of isocortical and hippocampal astrocytes in the human brain. J Neurosci. 2014 Feb 5;34(6):2285-98. doi: 10.1523/JNEUROSCI.4037-13.2014. PMID: 24501367.

Shigemoto-Mogami Y, Hoshikawa K, Goldman JE, Sekino Y, Sato K. Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone. J Neurosci. 2014 Feb 5;34(6):2231-43. doi: 10.1523/JNEUROSCI.1619-13.2014. PMID: 24501362.

Collins-Praino LE, Francis YI, Griffith EY, Wiegman AF, Urbach J, Lawton A, Honig LS, Cortes E, Vonsattel JP, Canoll PD, Goldman JE, Brickman AM. Soluble amyloid beta levels are elevated in the white matter of Alzheimer's patients, independent of cortical plaque severity. Acta Neuropathol Commun. 2014 Aug 17;2(1):83. doi: 10.1186/s40478-014-0083-0. PMID: 25927863.

Mela A, Goldman JE. CD82 blocks cMet activation and overcomes hepatocyte growth factor effects on oligodendrocyte precursor differentiation. J Neurosci. 2013 May 1;33(18):7952-60. doi: 10.1523/JNEUROSCI.5836-12.2013. PMID: 23637186.

Tang G, Gutierrez Rios P, Kuo SH, Akman HO, Rosoklija G, Tanji K, Dwork A, Schon EA, Dimauro S Goldman J,  Sulzer D. Mitochondrial abnormalities in temporal lobe of autistic brain. Neurobiol Dis. 2013 Jun;54:349-61. doi: 10.1016/j.nbd.2013.01.006. Epub 2013 Jan 17. PMID: 23333625.

Sosunov AA, Guilfoyle E, Wu X, McKhann GM 2nd, Goldman JE. Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease. J Neurosci. 2013 Apr 24;33(17):7439-50. doi: 10.1523/JNEUROSCI.4506-12.2013. PMID: 23616550.

Jang ES, Goldman JE. Pax6 expression is sufficient to induce a neurogenic fate in glial progenitors of the neonatal subventricular zone. PLoS One. 2011;6(6):e20894. doi: 10.1371/journal.pone.0020894. Epub 2011 Jun 17. PMID: 21698109.

Quan PL, Wagner TA, Briese T, Torgerson TR, Hornig M, Tashmukhamedova A, Firth C, Palacios G, Baisre-De-Leon A, Paddock CD, Hutchison SK, Egholm M, Zaki SR, Goldman JE, Ochs HD, Lipkin WI. Astrovirus encephalitis in boy with X-linked agammaglobulinemia. Emerg Infect Dis. 2010 Jun;16(6):918-25. doi: 10.3201/eid1606.091536. PMID: 20507741.

Tian R, Wu X, Hagemann TL, Sosunov AA, Messing A, McKhann GM, Goldman JE. Alexander disease mutant glial fibrillary acidic protein compromises glutamate transport in astrocytes.  
J Neuropathol Exp Neurol. 2010 Apr;69(4):335-45. doi: 10.1097/NEN.0b013e3181d3cb52. PMID: 20448479.

Tang G, Perng MD, Wilk S, Quinlan R, Goldman JE. Oligomers of mutant glial fibrillary acidic protein (GFAP) Inhibit the proteasome system in alexander disease astrocytes, and the small heat shock protein alphaB-crystallin reverses the inhibition. J Biol Chem. 2010 Apr 2;285(14):10527-37. doi: 10.1074/jbc.M109.067975. Epub 2010 Jan 28. PMID: 20110364.

Mela A, Goldman JE. The tetraspanin KAI1/CD82 is expressed by late-lineage oligodendrocyte precursors and may function to restrict precursor migration and promote oligodendrocyte differentiation and myelination. J Neurosci. 2009 Sep 9;29(36):11172-81. doi: 10.1523/JNEUROSCI.3075-09.2009. PMID: 19741124.

Lin G, Mela A, Guilfoyle EM, Goldman JE. Neonatal and adult O4(+) oligodendrocyte lineage cells display different growth factor responses and different gene expression patterns.
J Neurosci Res. 2009 Nov 15;87(15):3390-402. doi: 10.1002/jnr.22065. PMID: 19360905.

Lin G, Goldman JE. An FGF-responsive astrocyte precursor isolated from the neonatal forebrain. Glia. 2009 Apr 15;57(6):592-603. doi: 10.1002/glia.20788. PMID: 19031440.

Canoll P, Goldman JE. The interface between glial progenitors and gliomas. Acta Neuropathol. 2008 Nov;116(5):465-77. doi: 10.1007/s00401-008-0432-9. Epub 2008 Sep 11. Review. PMID: 18784926.

Tang G, Yue Z, Talloczy Z, Goldman JE. Adaptive autophagy in Alexander disease-affected astrocytes. Autophagy. 2008 Jul;4(5):701-3. Epub 2008 Apr 3. Review. PMID: 18414043.

Tang G, Yue Z, Talloczy Z, Hagemann T, Cho W, Messing A, Sulzer DL, Goldman JE. Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. Hum Mol Genet. 2008 Jun 1;17(11):1540-55. doi: 10.1093/hmg/ddn042. Epub 2008 Feb 14. PMID: 18276609.

Ivkovic S, Canoll P, Goldman JE. Constitutive EGFR signaling in oligodendrocyte progenitors leads to diffuse hyperplasia in postnatal white matter. J Neurosci. 2008 Jan 23;28(4):914-22. doi: 10.1523/JNEUROSCI.4327-07.2008. PMID: 18216199.

  • Glial Development and Pathology 
  • Tuberous Sclerosis/Epilepsy/Autism Spectrum Disorders