Kristin K. Baldwin, PhD

Kristin K. Baldwin, PhD


Kristin K. Baldwin is an American scientist who is a professor at the Department of Genetics and Development at Columbia University. Her research focuses on using reprogrammed and induced pluripotent stem cells to identify mechanisms and therapies related to human genetic risk for neurologic and cardiovascular disease. Her lab also studies how disease and aging affect the genome; they have used cloning to produce the first complete genome sequence of a single neuron and helped assess the effect of aging on induced pluripotent stem cells that may be used for cell therapies. They also design bespoke neuronal cells in a dish to understand brain function and disease. Baldwin's earlier work included being the first to clone a mouse from a neuron and being one of three groups to first produce an entire mouse from a skin cell by generating induced pluripotent stem cells. epigenetic changes of the genome and the brain.

  • Kumar A, Thomas S, Wong K, Lo Sardo V, Cheah D, Hou Y-H, Placone JK, Tenerelli K, Ferguson W, Torkamani A, Topol E, Baldwin KK, and Engler AJ. ​Mechanical activation of non-coding-RNA-mediated regulation of disease-associated phenotypes in human cardiomyocytes. Nature Biomedical Engineering. 2019, in press. doi: 10.1038/s41551-018-0344-5.

  • Lai JI, Nachun D, Petrosyan L, Throesch B, Campau E, Gao F, Baldwin KK, Coppola G, Gottesfeld JM, Soragni E. Transcriptional profiling of isogenic Friedreich ataxia neurons and effect of an HDAC inhibitor on disease signatures. J Biol Chem. 2018 Dec 14. pii: jbc.RA118.006515. doi: 10.1074/jbc.RA118.006515. PMID: 30552117

  • Lo Sardo V, Chubukov P, Ferguson W, Kumar A, Teng EL, Duran M, Zhang L, Cost G, Engler AJ, Urnov F, Topol EJ, Torkamani A, Baldwin, KK. Unveiling the role of the most impactful cardiovascular risk locus through haplotype editing. Cell. 2018 Dec 13;175(7):1796-1810.e20. doi: 10.1016/j.cell.2018.11.014. Epub 2018 Dec 6.

  • Tsunemoto RK*, Lee, S*, Szűcs A, Chubukov P, Sokolova I, Blanchard JW, Eade KT, Bruggemann J, Wu C, Torkamani A, Sanna PP, Baldwin, KK.  Diverse reprogramming codes for neuronal identity. Nature. 2018 May;557(7705):375-380. PMID: 29743677​* these authors contributed equally.

  • *Eggan, K., *Baldwin, K., Tackett, M., Osborne, J., Gogos, J., Chess, A., Axel, R. and Jaenisch, R.  Mice cloned from olfactory sensory neurons. Nature. 04 March 2004. 428: 44-49. * these authors contributed equally.