Gwyneth M. Card, PhD
Research Interest
Gwyneth Card is interested in the neural mechanisms and circuit architectures that underlie visually guided behavioral choices in the fly. Specifically, Card and her team study Drosophila escape behavior in ecologically relevant situations, combining high-throughput, high-resolution behavioral quantification with genetic, electrophysiological, and functional imaging techniques. Their aim is to understand the neural process involved when a fly chooses to perform a given escape behavior, to identify candidate neurons involved in coordination and choice of escape behaviors, and to link a neuron’s responses directly to an action.
- A searchable image resource of Drosophila GAL4 driver expression patterns with single neuron resolution. Meissner GW, Nern A, Dorman Z, DePasquale GM, Forster K, Gibney T, Hausenfluck JH, He Y, Iyer NA, Jeter J, Johnson L, Johnston RM, Lee K, Melton B, Yarbrough B, Zugates CT, Clements J, Goina C, Otsuna H, Rokicki K, Svirskas RR, Aso Y, Card GM, Dickson BJ, Ehrhardt E, Goldammer J, Ito M, Kainmueller D, Korff W, Mais L, Minegishi R, Namiki S, Rubin GM, Sterne GR, Wolff T, Malkesman O; FlyLight Project Team. Elife. 2023 Feb 23;12:e80660.
- Synaptic gradients transform object location to action. Dombrovski M, Peek MY, Park JY, Vaccari A, Sumathipala M, Morrow C, Breads P, Zhao A, Kurmangaliyev YZ, Sanfilippo P, Rehan A, Polsky J, Alghailani S, Tenshaw E, Namiki S, Zipursky SL, Card GM. Nature. 2023 Jan;613(7944):534-542.
- A functionally ordered visual feature map in the Drosophila brain. Klapoetke NC, Nern A, Rogers EM, Rubin GM, Reiser MB, Card GM. Neuron. 2022 May 18;110(10):1700-1711.e6.
- Context-dependent control of behavior in Drosophila. Oram TB, Card GM. Curr Opin Neurobiol. 2022 Apr;73:102523.
- A population of descending neurons that regulates the flight motor of Drosophila. Namiki S, Ros IG, Morrow C, Rowell WJ, Card GM, Korff W, Dickinson MH. Curr Biol. 2022 Mar 14;32(5):1189-1196.e6.
- Functional architecture of neural circuits for leg proprioception in Drosophila. Chen C, Agrawal S, Mark B, Mamiya A, Sustar A, Phelps JS, Lee WA, Dickson BJ, Card GM, Tuthill JC. Curr Biol. 2021 Dec 6;31(23):5163-5175.e7.
- Multi-regional circuits underlying visually guided decision-making in Drosophila. Cheong HS, Siwanowicz I, Card GM. Curr Opin Neurobiol. 2020 Dec;65:77-87.
- Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS. Lacin H, Williamson WR, Card GM, Skeath JB, Truman JW. Elife. 2020 Mar 27;9:e55007. doi: 10.7554/eLife.55007.
- State-dependent decoupling of sensory and motor circuits underlies behavioral flexibility in Drosophila. Ache JM, Namiki S, Lee A, Branson K, Card GM. Nat Neurosci. 2019 Jul;22(7):1132-1139.